kiva.org is a great site. Kiva allows you to lend money to people in less wealthy parts of the world in order to help them better their standard of living.
So far I have made a few loans. You can see my lender profile. One of the things that I like about Kiva is that you are directly helping a specific person as opposed to donating to a charity which disburses the money as they see fit.
I know there are many worthy charities that do a great job of helping people who are less fortunate. But, I like knowing exactly to whom my money is going.